Severe heterozygous FH is defined as having a starting LDL above 300 mg/dL, affecting about 10% of the heterozygous FH population, and these patients are difficult to get below 100 mg/dL even with triple therapy.

“so we say that if you're starting LDL is above 300 you have severe heterozygous FH and that's about 10 of the overall heterozygous of age population of course when you start at 300 and you have a Statin that takes off 45 then another new Baseline 15 to 20 and then then you can calculate that it's not that easy to get below 100.”