Individuals with genetic variants affecting PCSK9 have an increased risk of type 2 diabetes.

“the pcsk9 Tio which is associated with a a lowered pcsk9 lowered pcsk9 means lower LDL and lower activity of pcsk9 was associated with a risk of type two diabetes in increased body mass index waste circumference waste of hip ratio diastolic blood pressure type 1 diabetes and insulin resuse”

“Moreover these specific pcsk9 variants were associated with adverse metabolic consequences including increased fasting glucose increased body weight and an increased waste to hip ratio”

“so for every 38.6 7 milligrams per deciliter of ldlc that was reduced for people who had these genetic variants with for pcsk9 there was a subsequent 19% increase in incidents of diabetes”