2-deoxy-D-glucose (2-DG) inhibits the glycolytic pathway, reducing endogenous antioxidant capacity in cancer cells and making them vulnerable to oxidative stress.

“like the 2dg will inhibit a glycolytic pathway that drives the pentose phosphate pathway and that pentose phosphate pathway is responsible for enhancing the endogenous antioxidant capacity of cells so it makes the cancer cells even more vulnerable to oxidative stress”