CTLA-4 antibody therapy can cause life-threatening gut inflammation, perforation, and death. — Whalespan
CTLA-4 antibody therapy can cause life-threatening gut inflammation, perforation, and death.
⚠ High risk
We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
✕NOTSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“You give a C. teliofer antibody and where does the most life-threatening chaos erupt? It's at the gut. You've unleashed... this pre-existing force that's at work all day, every day in this very immunologically active environment. And it starts attacking normal colonic tissue and can perforate the colon from which patient then dies.”
“there are also very nasty side effects of checkpoint inhibitors and for every patient we see who has a response to them some of the autoimmunity can be quite devastating and in fact vitiligo for a patient with melanoma might not be such a fatal form of autoimmunity but certainly when people have life-threatening enterocolitis yes they're cancer-free but they die from bowel disease that follow”