Many osteoarthritis animal models involve inducing pain and testing painkillers, which may not be highly relevant to human osteoarthritis.

“so the animal model for osteoarthritis is an ACL injury which is still true in humans but there are a few different models for us - arthritis and so really one of the things we've learned is that when you attempt to model disease there are lots of off-the-shelf models that people have built for things like osteoarthritis because they're making a painkiller so they do things like hurt the animals knee and then give it a painkiller how relevant is that to osteoarthritis in a human it's not”