Paul Saladino· MD
roughly 20 to 25% of people are non- metabolizers of opioids
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
roughly 20 to 25% of people are non- metabolizers of opioids
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
if you're going to force these people to opioids we should probably implement a pharmacogenetic test to identify is this patient at risk of being a slow metabolizer and dying are they at risk of being a fast metabolizer and not experiencing the benefits of the drug or are they a non- metabolizer