Approximately 20-30% of people experience an opposite reaction to pain relief from opiates, and some may develop hyperalgesia.

“you said 20 to 30 percent of people experience that actually 20 30 % of people experience that from the beginning where they experienced an opposite reaction to to pain relief but I'm saying people who traditionally get pain relief who require more and more and more for the same amount of pain relief suddenly they are experiencing a hyperalgesia an increase in pain whereas before a month ago you know two months ago they were actually getting pain relief”