Delivering gene therapy to the brain is challenging due to its protected nature and requires methods beyond simple intravenous infusion, such as intranasal delivery, intrathecal injection, or direct injection into ventricles.

“brain is a complex organ so you want to be able to get it throughout the brain for for function ... there are multiple ways to access the brain it's obviously a protected space in terms of the bloodb brain barrier ... some cases we do intrathecal ... for anyone who's thought about chemotherapy that we give for brain cancer sometimes we actually have to do it Into The ventricle ... it's not as simple as a simple intravenous infusion it's not like we can just give it peripherally and get it to the brain where we need to”