Strategies to mitigate immune response to gene therapy include drug dampening, novel viruses, and hyperfractionation.

“the other thing you can do is you can actually there are new drugs that can dampen down down or tack down the immune response so you can think of the immune response as a dial what you can do is you can dial the immune response down so that the immune response doesn't respond so briskly uh to the gene therapy you can hide the virus so you can make a virus such that your body has not seen such a virus before so you can actually use a novel kind of virus that has not been that won't raise a Brisk immune response the fourth thing you can do is you can actually give the gene therapy in small doses it's called hyperfactionation so that uh fractionation small fractions so that the immune system doesn't again go berserk seeing this massive bolus of a dose of virus”