There is likely a genetic susceptibility to opioid dependency.

“there's got to be a genetic susceptibility to this because there are many people who take tons of opioids during you know say a post you know post-operative recovery from surgery and you know they take tons of the stuff and then when they have to stop it they stop it and that's the end of it and yet there are other people for whom that's not true so do we have a sense of what that what that genetic susceptibility looks like and is it more important is it possible to predict that a priori”