The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I would love to see you have on your show a real pharmacologist who knows the answers to that question I would love to talk to a real pharmacologist and ask him or her hey aren't there differences between men and women in the rate at which drugs are excreted and why isn't that informing our recommendations for drug Doses and people
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Rich when you talk about the difference in the pharmacokinetics between male and female mice we can only extrapolate and say that our you know cytochrome p450 system as humans must have sex differences oh yeah that's well documented absolutely but what I can't tell you for the life of me rich is one drug that I'm aware of that we really differentially dose in males and females Beyond a weight difference in other words we don't seem to take into account that difference when we give a person an antibiotic or a Statin or a chemotherapy they're all based on either weight or nothing at all