Limited vision restoration in LCA patients treated with gene therapy may be due to retinal inability to regenerate, inefficient delivery systems, and less-than-100% efficient gene editing.

“you know the retina doesn't regenerate and so you have to be able to um to deal with if it's already degenerating you have to deal with what is what is what is left in the Rea and so what you can restore is really capped by whatever that's already left there and uh and and plus there's also inefficiencies in the Delivery Systems you're not restoring 100% of the cells uh and then if you're layering on Gene editing on top of it which also has some sort of less than 100% efficiency when you multiply that all together uh that's why you're not getting um s full restoration”