Peter Attia· MD
right now the answer is no uh we have no way to use them against solid cancers again because the solid cancers to be treated with a car T Cell you have to have a molecule on the cell surface that's unique to cancer we originally didn't fully realize quite how sensitive they could be and when we targeted molecules that were on normal cells patients died devastating events in the development of the of the treatment but monoc antibodies were first described about 45 years ago and no one has found unique monoclone antibodies against molecules un uniquely on cancer cells and not normal cells and that's what you need to make a chimeric t- cell receptor you need an antibody that you can put into a lymphocytic and antibody uh antibodies just have not evolved to recognize individual cell surface molecules on cancer which are shared by normal cells whereas conventional tea cells do because internal proteins then get digested and brought onto the surface so right now there's very little Prospect for car te cells being useful for the treat treatment of solid tumors