Smaller CRISPR-associated proteins are being engineered but may have trade-offs in specificity or activity compared to Cas9.

“and and there are some out there but sometimes and usually they're not as specific or not as active as casai and so there are tradeoffs uh to using some of those systems”

“you need the Best of Both Worlds you need uh a cast Associated protein that is small and you want to be able to keep the guide RNA small small right that that's the Holy Grail”