Peter Attia chooses not to take weight loss drugs due to concerns about potential long-term side effects, such as an increase in resting heart rate and a decrease in heart rate variability.

“for somebody who is quite a risk taker and I am quite a risk taker I've seen I am when it comes to my health I would argue I'm quite a risk taker but I've watched countless patients take these drugs and as I've shared with you and others without exception the resting heart rate overnight goes up about 10 beats per minute and I don't know what it is about that fact and the fact that heart rate variability goes down slightly that just has me asking the question for me personally is it worth a trade on”