The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so the group that got .5 daily had 35 adverse effects and each of the treatment groups had about the same number so i mean there were 53 groups in each of the three arms 59 in the placebo so the 21 you might discount that slightly but it basically went from 35 to 46 to 109.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the next line in the table tells you how many people actually had adverse effects so not just the total adverse effects and this was surprisingly constant so in the placebo group it's 12 in arm 1 it's 22 in arm 2 it's 20 and arm 3 is 27.
the other thing that really stood out to me though in terms of side effects was mouth ulceration now that's the side effect i remembered the most from residency was the patients getting aptos ulcers with their daily dose of rapamycin and most of them were getting more than 0.5 daily so most of the patients that i wrote my recollection was that two to four milligrams was a very common daily dose for rap immune and again this is rad001 so it's a different vehicle but it's comparable and so 0.5 daily would definitely be lower than what i was used to seeing people get and yet 11 and a half percent of these folks had mouth ulcerations whereas the people getting 0.5 daily were at 0.5 once a week was about 4 percent and 20 once a week was about 17