Phase three clinical trials are large-scale, randomized, blinded studies comparing standard of care versus standard of care plus a new agent to detect side effects and measure efficacy.

“you then proceed to phase three and here a phase three is a really rigorous trial this is a huge step up it's typically a log step up in the number of patients so you'd you know you're talking potentially thousands of patients here and this is absolutely a placebo controlled trial or not necessarily placebo but it can be sort of standard of care versus standard of care plus this new agent but it is randomized whenever possible it is blinded and with drugs that's always possible um and these are typically longer studies”