RTB101 was the most effective drug for decreasing respiratory tract infections in a study, and a combination with RAD001 improved flu vaccine response.

“the best drug was bez235 which we now call rtb101 in terms of decreasing respiratory tract infections the combination also worked interestingly the combination as well as rad001 improved the flu vaccine response but the bez235 or rtb-101 did not”

“the biggest effect was observed with just the catalytic inhibitor alone the second biggest effect wait the catalytic inhibitor was a new molecule yes it's a new compound it was in that paper it was called bez235 and this is the molecule licensed by restore bio so bez235 is not rad001 combined with something else no we tested the combination and it also decreased respiratory tract infections and the combination was the best at improving the flu response but the single catalytic inhibitor was the best at preventing respiratory tract infections”

“in the first study published in 2014 that we've been discussing respiratory tract infections and infections in general were observed to be decreased in the drug treated group compared to the placebo by reviewing the adverse event listings this was not something we had considered a priori but we recognized decreased infections could be a consequence of improved immune function which is why we looked in the first place in the listings”