RTB-101 was used clinically at doses where some efficacy might be expected without significant side effects.

“but it is possible at least for that molecule to use it clinically at dose is where there's some reason to believe there might be some efficacy before letting David chime in can I just ask a question to clarify that um in the rtb 101 trial um did they didn't they combine it with another agent they did with ever alignment so they had two arms one was the combination and one was rtb 101 alone yeah yeah yeah no so so um I think Matt look I'm sorry I meant to my my shaking was that I was agreeing with you and and I was I actually was that that's study that that that manic did after I was confounded by that study and perplexed because this RTP which they 10 one they renamed I”