Base editing uses Cas9 to guide a deaminase enzyme to modify a single base and was developed by David Liu.

“David Le uh developed a methodology yeah also yeah he's a colleague of mine and he developed a technology called base editing and base editing allows you to use cast 9 you you get rid of the DNA cleaving activity of cast 9 and so so it simply goes and binds the DNA so you use it as kind of a guidance system to direct a different enzyme called the dmas to be able to go and and chemically modify a single base”