Inhibitory drugs like benzodiazepines, opiates, and psychedelics do not cause receptor downregulation or withdrawal symptoms because they do not stimulate neurons.

“so not every drug Fry's neurons so but cocaine does yeah help me understand how alcohol fits into this because alcohol is of course a gap ethanol per se as a GABA agonist so it should be at least depressing in that sense but yet ethanol has some of these negative properties in the brain that you've just alluded to well what the problem is ethanol in the brain also because it's polar and it dissolves lipids it also creates acetaldehyde so that's the first step in terms of metabolism of ethanol which then can cause that mired reaction because you've made an aldehyde which then generates reactive oxygen species so you can kill neurons not necessarily from excitation but from the biochemistry of the molecule”