Peter Attia· MD
you are protected against that drop if your CTP activity is low because it's like having a CTP inhibitor on board which stops removing cholesterol from HDL
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
you are protected against that drop if your CTP activity is low because it's like having a CTP inhibitor on board which stops removing cholesterol from HDL
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it's way more complicated than that no it's way more complicated and it's most likely has to do with the Scavenging function of lipoproteins so if your CDP is low when you get septicemia your HDL stays high and it's very likely that the HDL particle functions as a sink four and the toxins and everything else and so having a high HDL and a constant High HDL during septicemia is a very good thing
there are two groups in the world one in Vancouver and one in Leiden that have shown that if you're born with a loss of function variant in CTP you are much better protected against septicemia and not a little bit but like mortality big effect actually