The free plasma concentration of ivermectin achievable in humans is about 250 times lower than the concentration required in vitro to reduce SARS-CoV-2 viral replication.

“The problem was is that when you look at the actual dosing of ivermectin in a human being, you only get about 0.28 micromolar. So that's a number of orders of magnitude, if you will, reduced than the concentration that you would need to have in the cell to get that. And so this paper here that was published in the "British Journal of Clinical Pharmacology" said that "The free plasma concentration of ivermectin would need to be 250 times lower," was actually 250 times lower than the concentration required to reduce viral replication of SARS-CoV-2 in vitro.”