Inhibiting hexokinase with drugs like lonitamine can create an energy crisis in glioblastoma cells, triggering autophagy and cell death.

“So the idea then is to use like something like lonitamine, like inhibit hexokinise, too. So uh there are enzymes glycolytic enzymes that are upregulated. There are transporters that are upregulated and if you create an energy crisis in GBM cells that's great enough then you trigger autophagy and then you trigger uh cell death because there's an incredible glycolytic energetic demand in glyobblasto cells and if that demand is not met then that triggers cell death pathways.”