Peter Attia· MD
it's uh it's of course when the same amount of a medication produces a lesser and lesser effect or when you require more and more of a medication to produce the same effect so for example we don't generally get tachyphalactic to tylenol right the acetaminophen if you take 500 milligrams and your headache goes away you know the next time you take 500 milligrams it does about the same thing