Rapidly developing tolerance to ketamine requires progressively higher doses with repeated administration in a short time window.

“the so these people that i was working with were very constrained subcultures so we have kind of these travelers they're like um people who live itinerant lives you know i don't know if you have something equivalent in in the us so it was amongst those groups um some of them called it kitty smack basically saying it's like an addictive drug like it was basically like heroin for kids i see so it's kind of the jv or junior version of heroin not quite as bad yeah for those people but there was zero information about it at the time and and they were not taking the drug the way it's given you know for depression they were taking grams and grams of it every day so these serious something important to say and what would what what would they experience i mean grams of this i had we'll come back and do the math on what that means but if they're taking high doses of this stuff daily were they taking it and then basically passing out in their apartments for hours and just dissociating on trips and no i mean they would be so a dose that would render someone completely yeah catatonic septic would be they would just tolerate it because it is the tachyphylaxis is like a rapidly developing tolerance and if you do administer ketamine repeatedly in a short time window you do need to give higher and higher doses”