Xanthine oxidase inhibitors like allopurinol are preferred for lowering intracellular uric acid to address cardiovascular and kidney disease.

“well the xanthine oxidase inhibitors are the best because the way uric acid works to cause cardiovascular disease and kidney disease and all these things appear to be through its actions inside the cell as we said works on mitochondria and it does all these things it's not it's work outside the cell so gout is really an extracellular deposition but when you're thinking about uric acid and its biologic effects that's an intracellular action so xanthine oxidase makes uric acid inside the cell so one of the best ways to reduce intracellular uric acid is to give us antioxidants inhibitory like allopurinol or phi boxes”