The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we saw decreased respiratory tract infections in elderly people treated with it in the phase to be study that restore bio ran again the same dose 10 milligrams once a day saw the same thing a decrease in respiratory tract infections
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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we learned that there was an upregulation of antiviral gene expression in peripheral blood leukocytes so a set of interferon stimulated genes responsible for antiviral activities was upregulated so we identified a candidate mechanism
we saw a 30 decrease in respiratory tract infections yes
the phase 2b study that restore bio ran showed that the most effective drug or drug combination for preventing respiratory tract infections was just rtb 101 alone at 10 milligrams
but if you think about where the world was five months later they might have made a different decision at that point with a drug that could potentially affect vaccine response and subsequent viral infections regardless that's all history but now Joan did go back and do a subsequent analysis on the data from that half completed phase three and in fact in those patients who got the rtb 101 there was a significantly lower risk of subsequent infection for certain viruses among them influenza viruses and Corona viruses not covid-19 because we didn't know about covid-19 when this was happening but Corona viruses as a class the people who'd gotten rtb 101 showed a significantly lower likelihood of a future laboratory confirmed viral infection
in cell culture models there was some data that rtb 101 induced antiviral gene expression so there was some you know at least somewhat plausible biological rationale for for the end point that they were going after which was if I remember correctly at least for the pivotal it wasn't so much vaccine response it was subsequent infections and so the the thought was if you can both boost vaccine response and enhance uh resistance to subsequent infections that might be a combination that was that was useful