Anavar affects glucocorticoid signaling at a transcriptional level and can be anti-catabolic by blocking the actions of glucocorticoids.

“So, Anavar doesn't technically downregulate the gluccoid receptor. It does affect gluccocorticoid or cortisol signaling, but at a transcriptional level. So, maybe this is splitting hairs, but he should know this if he's going to take this regimen without any doctor supervision. Anavar does not downregulate the gluccoid receptor, but it can be anti-catabolic blocking the actions of gluccocorticoids like cortisol because it's an androgen. So at a transcriptional level, it can be anti catabolic.”