Oxandrolone (Anavar) was FDA approved for multiple indications but was later deemed to have no efficacy, leading to its withdrawal.

“My understanding and I may be not entirely correct but it was FDA approved for many indications and then basically the FDA determined based on and this seemed like kind of a nonsense thing but a meeting in the 80s where they determined that anabolics in particular anavar by extension had no efficacy anymore essentially and for whatever reason they determined that that decision back then if you go far back enough you can find studies where they're like anabolic steroids aren't performance-enhancing and it's like obviously nonsense but at that time that was what the literature available showed and it almost seems like they're leaning they're you know they're leaning on some of that in order to justify pulling it we don't think it is useful for all of these approvals anymore and then there's pressure from that for all of these companies that have generic approved versions of it to subsequently pull it as well”