Traditional ADT with an LHRH agonist can lead to long-term suppression of the hypothalamic-pituitary axis, resulting in a low probability of normal testosterone recovery.

“the problem with that is that it is very very um durable it lasts a it's given as a a Depot that lasts a long time it's helpful for the patient but the probability that the patient would Rec ever recover normal testosterone is very low less than 50% of men who do uh why is that because of the long-term effects on the hypothalamic pituitary axis it just gets shut down and or because as you know in the Aging male that that that whole you know fragile to begin with it's fragile to begin with”