Catalytic mTOR inhibitors are often very hydrophobic, making them difficult to dose in animal models without the use of detergents.

“the catalic Inhibitors are actually very challenging to use they're very hydrophobic molecules because the catalytic site of Emptor is like a very hydrophobic site so everyone who independently made these molecules ended up with very greasy molecules that are not easy to dose in in a mouse very hard to dose you got to put them in detergents and all these all these things that the mice don't like either”