Opioids pose the greatest physiological risk of acute and chronic mortality, followed by cocaine and amphetamine derivatives.

“so let's now simplify and talk about only harm to the individual so purely physiologic risk to self if i heard you correctly earlier heroin and fentanyl and its cousins occupy the top spot correct so aggregate greatest risk of acute and chronic mortality yes correct and then second you're putting the cocaine derivatives and then third would be the amphetamine derivatives so if we just look harm to to the user yes i mean crack okay crystal meth's probably more harmful than crack because it lasts longer in the body and the brain so i would generally crystals probably a bit more harmful to the user so it would be opioids crystal crack”