Peter Attia· MD
we talked about the Spicoli route and I guess the advantage of that route is it's relatively quickly the active ingredients become engaged with the receptors both peripherally and within the CNS in a very short period of time
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we talked about the Spicoli route and I guess the advantage of that route is it's relatively quickly the active ingredients become engaged with the receptors both peripherally and within the CNS in a very short period of time
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
that has the advantage it avoids first-pass metabolism it gets much more of the active drug into the bloodstream and to be distributed throughout the body so in theory you could actually lower the levels of drug that are necessary to do
because they're put into very very fast rapid dissolving tablets that disintegrate in about 15 seconds or so do they disintegrate under the tongue and therefore escape the first pass effect of the liver