Intramuscular and sublingual administration of ketamine have good bioavailability, and intranasal administration is also used medically for depression.

“intramuscular has got quite good availability in the blood and then there's people starting to use things like sublingual administration so putting under the tongue um intranasal obviously is the root popularized by first the drug users themselves but then patented by um the pharmaceutical company and have now used that for their licensed form of ketamine and depression”