Ketamine can be cut with other substances, and analogues like methyl-ketamine may have higher toxicity, particularly to the bladder, and potentially higher abuse potential.

“i don't think it's it's normally particularly cut with things but it's something to be mindful of and why it's really important to take a small dose you know but ideally yeah obviously i think cautionary non-medical use well celia that's i mean this is super interesting i mean this is i've sort of been deliberately sort of ignorant of ketamine i don't know why i've sort of gone down the rabbit hole and trying to understand as much as possible about these other uh agents which ironically are tend to be the one that are schedule one and therefore not really readily available for clinical use outside of trials we do have many clinical trials here in the united states looking at in particular the use of psilocybin and mdma”