Rhonda Patrick· PhD
Normal chow diet. They were not fasted. And we found that their ketone body levels were going very high in the millimolar range. And, within a few hours, their histones were becoming hyperacetylated.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Normal chow diet. They were not fasted. And we found that their ketone body levels were going very high in the millimolar range. And, within a few hours, their histones were becoming hyperacetylated.
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And so we tested this by putting a pump under the skin of a mice with beta-hydroxybutyrate and then measuring histone acetylation throughout the mouse, and we found that histone acetylation marks were going up, suggesting that there was indeed an inhibition of HDAC.