Peter Attia· MD
so the control arm shouldn't have been sugar pill it should have been continuing the drugs that were working this is a trial called polo
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so the control arm shouldn't have been sugar pill it should have been continuing the drugs that were working this is a trial called polo
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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if you have a bracket germline mutation in pancreas cancer they did a randomized trial where they gave people four months of the standard of care full fearing ox therapy and they stopped it after a minimum of four months you could have had a little bit more but they stopped it after four months and randomized you to a lap rib or sugar pill and if you take olap rib you have a progression-free survival benefit which i can explain what it is in a second versus sugar pale but you don't have an overall survival benefit you're not living any longer