In a mouse model, a liver-specific knockout of mTOR complex 1 partially rescued a brain disorder, suggesting peripheral tissue signaling can impact brain disease.

“it was the liver specific knockout that led to partial Rescue of the disease so there could be a tissue signaling piece and that could be metabolic you could imagine inhibiting mtor complex one in the liver would lead to systemic metabolic effects so I think that's a case in point where you can get effects on a brain disorder”