Peter Attia· MD
disease risk was increased with slower nicotine metabolism but the added risk was abolished when adjusted for smoking heaviness
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
disease risk was increased with slower nicotine metabolism but the added risk was abolished when adjusted for smoking heaviness
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But nevertheless, uh, the authors used these genetic variants associated with nicotine metabolism to adjust for basically smoking heaviness. And again, we're not interested in the role of smoking. We're interested in the role of nicotine. Okay.
And it came away basically saying that the harm of smoking is due to the tobacco and tobacco related products, not due to the nicotine.
So um, disease risk was increased with slower nicotine metabolism, but the added risk was abolished when adjusted for smoking heaviness. because of course if you do this you have to adjust for smoking indicating that the main drivers of the outcomes um are the non-nicotinic components of cigarette smoke.
And it came away basically saying that the harm of smoking is due to the tobacco and tobacco related products, not due to the nicotine.