17-alpha estradiol administration in males leads to male-specific estriol production dependent on testosterone.

“he found two steroids they were members of the estriol family not estro die all but est3 all that were elevated at least 20 fold in males that got the drug and they were not elevated in females at all it was a male specific production of estriol when 17 Alpha estradiol was given to the males and we knew it was sex specific because if he castrated the males before the drug you didn't see the estriol production the conversion from estradiol to estriol dependent upon testosterone or some other testicular hormone”