High-dose probiotics (e.g., 400-800 billion CFUs) have shown benefits in studies for conditions like colitis or irritable bowel syndrome.

“Many of the studies at the time, the bacteria was...the brand was called VSL#3. The formulation was like done again, and it was called Visbiome. But many of the publications...clinical studies, you know, including as well as animal studies, but there have been benefits, for example, on like colitis or irritable bowel syndrome with taking either 400 or 800, you know, colony-forming units, so like, you know, 800 billion, so much higher doses than you would find in something on the shelf of a grocery store.”