Current mass adoption of hormone therapy primarily involves transdermal estradiol patches and micronized progesterone, or progesterone-coated IUDs, which differ from older formulations.

“most women these days are using you know the vivelle dot or one of the topical FDA patches which is just pure estradiol as you alluded to earlier most women these days are taking micronized Progesterone which is a bioidentical progesterone or foregoing oral progesterone altogether and using a progesterone coated IUD which seems to offer the same degree of local endometrial protection without any of the systemic effects for some women who can't tolerate that”