Upregulating AMPK and not upregulating mTOR too much are key to longevity, implying excessive protein intake might reduce lifespan.

“he very strongly believes that you want to upregulate ampk to live longer and you want to not upregulate mtor too much to live longer and I know you've talked about rapy which you know sort of has effects that would go along with what saying so he might argue from that point of view that too much protein would reduce longevity”