Peter Attia· MD
there's a lot of different methods of creating PRP and there's a lot of variety and so that's one of the problems with the studies that are out there that there's inconsistent methods
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
there's a lot of different methods of creating PRP and there's a lot of variety and so that's one of the problems with the studies that are out there that there's inconsistent methods
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if I were gonna make the case that PRP is better than the studies led on and I'm not making that case because I actually don't know but if you if you believe that PRP is better than this studies suggest you'd probably also believe that the reason the studies are under finding benefit is that they're underpowered because of the heterogeneity and approach and the inconsistency in patient selection
the studies about PRP are somewhat imperfect because there's there's so many different commercial preparations of PRP and there's sort of general categories there's leukocyte rich PRP so high in white count white cells is leukocyte poor those were deliberate design choices or those are yes methodology difference yes yes design choices and then again several different types of preparations for PRP so you're dealing with a very heterogeneous starting point and so one PRP injection doesn't isn't the equivalent of another PRP injection
Now you could spin it twice you could do two spin technique you can spin it so that you're keeping some of the white blood cells so we've categorized it into lucsy Rich PRP and Lucy poor PRP and this is a very simplified way that we think about it right now and there's certainly if we fast forward 10 years from now this will be a ridiculous conversation because we just are sort of in our infancy of understanding what we're doing here