Psychedelics, including mescaline and psilocybin, have been used by different civilizations for centuries or millennia.

“these compounds many of the classic psychedelics let's just for the sake of argument we'll leave LSD out of the running for a number of reasons including just the the political PR baggage that that acronym carries if we're looking at say mescaline which is found in peyote it's found in the San Pedro or Wauchula cactus in South America among other places and we're looking at psilocybin found in quite a few different mushrooms these are compounds that have been used for hundreds of years probably millennia by different civilizations”