The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
In addition to that, there's a reduction in what's called the hierarchical organization of the brain. Typically sensory information comes in from the outside environment. [...] When psilocybin is present in the system, there's a broadening of the flow of that information from the bottom up as well.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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Essentially, what I'm describing here is that serotonin to a receptor activation allows for more broad, less precise, and less hierarchical activation of brain circuitry. And when I say hierarchical, what I mean is that normally things go from periphery, from eyes, to thalamus, to visual cortex. However, when under the influence of psilocybin, as I mentioned before, even in the eye mask, the visual cortex is going to be very activated even in the absence of any visual input.
The brain's top-down hierarchy, originating in the pre-frontal cortex, was attenuated. This reduced predictive filtering, leading to a flood of bottom-up sensory information and heightened bodily perception