At lower doses of rapamycin, such as those used in healthspan/lifespan studies (e.g., ITP studies), CNS penetration may be limited, and tissue distribution is likely not uniform.

“but but again very talented people have argued differently than that but but our experience certainly was that the brain seemed more resistant in fact sometimes you would get you could stain the brain you'd see almost like a peripheral inhibition like it kind of permeated a little bit from sort of you know blood vessels in the sort of Dura and stuff but but now but I think the more relevant question Peter is at these lower doses that people take potentially for for health span lifespan studies in the ITP studies what what is what are the tissues that are most affected Matt may know but but but I don't know and my feeling is that it's not going to be so equal in those situations those are very low doses compared to what we would give to Romy and so my my my bet is that there's much more variation and that might actually be very interesting to to know”