The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
i have a protocol where i think sort of go on for eight weeks and off for six or i think it's on for eight off for five so it works out to be exactly a quarter but truthfully you know without more advanced testing i'm really making it up
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The "high risk" framing here is the right call. I've had three patients ask about rapa this month and none of them grasped the immunosuppression tradeoff until I walked them through it.
The PEARL trial framing in the dossier is the clearest writeup I've seen for a non-specialist. Worth linking from the AMA pages too.
I'm on 6mg/week, year two. Tracking IL-6, fasting glucose, lipids. Happy to share the spreadsheet if Whalespan wants longitudinal user data.
The dosing variance across the advocate camp is staggering. 3mg, 5mg, 8mg, biweekly, weekly… brief is right that "monitor or specialist only" is the responsible read.
i you know i think two and a half years ago when i started i was very strict about eight on six off eight on six off eight on six off and i don't know a little while ago i just sort of said yeah i'm just not coming off and i wish i had a biomarker to point to i wish i had some way of measuring whether this is the right thing to do or if there's a or if you know eight four eight four eight four right there's a symmetry to eight five because you'll get through exactly four cycles a year maybe i do eight five eight five eight five eight five
i've also done the cycling on and the cycling off
so i've i've tried uh eight to ten week courses of rapamycin a couple of times um the most recent time it was because this was probably spring of 2019
we're doing once a week now
I have taken rapamy I have not seen any effect on my blood sugar
Rapamycin extends median and maximum lifespan in mice across multiple lab strains and dosing protocols.
Rapamycin will extend human lifespan by 5+ years at standard weekly dosing.
Weekly rapamycin dosing in healthy adults shows favorable safety and immune markers in early observational data.
Chronic low-dose rapamycin imposes an immune trade-off that outweighs the longevity hypothesis for most healthy adults.
mTORC1 inhibition is the mechanistic backbone for rapamycin's healthspan effects in mammals.
The PEARL trial showed an acceptable 48-week safety profile in healthy adults on weekly rapamycin.