In mitochondrial disease in the brain, rapamycin appears to fix the issue of massive autophagosomes that are unable to digest mitochondria.

“my intuition is that at least for some diseases one of the things that rapamycin does and I don't really understand the molecular biology here it seems to alleviate that block so you actually get productive etapa G working again and again I don't know exactly how that works but that's what it seems to me is happening and so we have seen some evidence for this in mitochondrial disease in the brain where if we look in the brain we can see these sort of massive auto phagosome 'z that are trying to digest mitochondria that can't do it while the disease is progressing and somehow rapamycin fixes that”